Spangenberg is the third player in Padres history to have multiple RBIs in his big league debut.
Cory Spangenberg was the team's first-round pick in 2011.
Trevor Hoffman ranks second on the all-time saves list with 601 saves, 552 of them while wearing a San Diego uniform.
Hyun-Jin Ryu came off the disabled list to pitch four-hit ball over seven innings, and Matt Kemp singled in the go-ahead run.
Petco Park did not fare too well on the list.
Rene Rivera tied the game with a home run in the ninth inning, then won it with an RBI single in the 10th inning.
Tyson Ross pitched 6 1-3 strong innings, Abraham Almonte had two RBIs and the San Diego Padres beat Milwaukee 4-1.
Kyle Lohse pitched six strong innings while Ryan Braun and Aramis Ramirez hit home runs.
Tyson Ross gave up a 2-run homer in the eighth inning in the 2-1 loss.
Adam Wainwright won his 15th game to tie for the major league lead.
Padres have won six of their last eight games.
The rookie's first career home run helped the Padres win their fifth straight game.