Another person, only identified as a woman, was also stabbed and brought to Mercy Hospital for treatment. Her condition and name have not been released.
Several people were taken into custody following the incident but no arrests have been announced. It's still unclear what led up to the incident.
SDPD said they are looking for a Hispanic male last seen running from the canyon along with an unknown female. Anyone with information is asked to call SDPD's Homicide Unit at 619-531-2293 or Crime Stoppers at 888-580-8477.