San Diego Padres right-hander Edwin Jackson is pitching a no-hitter through six innings against the San Francisco Giants.
Jackson had struck out three, walked four and thrown 72 pitches Sunday in his first big league start since 2014.
The Padres are the only team in the majors that has never pitched a no-hitter. San Diego played its first game in 1969.
The Giants have the best record in baseball this season. The Padres lead 2-0 at Petco Park.
Jackson pitched a no-hitter in 2010 for Arizona, walking eight and throwing 149 pitches to stop Tampa Bay. The 32-year-old was signed to a minor league deal on June 20 after being cut by Miami.
Jackson was promoted from Triple-A earlier Sunday to start in place of All-Star Drew Pomeranz, who was traded to Boston on Thursday. San Diego is his 11th big league club.