Neighbors describe hearing a loud explosion before seeing flames.
Firefighters say following the fire, four of the five people inside the home were accounted for.
The fifth person was later found dead inside the home, according to authorities.
Firefighters described having a difficult time entering the home. "A lot of the windows in this structure were boarded up. When crews pulled up to the front door was padlock shut from the outside," said San Diego Fire Battalion Chief John Fisher.
The cause of the fire remains under investigation.
4 residents self evacuated. This is the 10900 block of Westmore Circle. A shot of the back of the residence. Also embers were flying which created danger for neighboring homes. Crews mitigated. pic.twitter.com/e6LEF7gjGa