A crash involving at least four vehicles forced authorities to close Genesee Avenue between Governor and Nobel drives in University City.
The crash happened shortly before 11 a.m. in the 6900 block of Genesee Avenue, according to San Diego police.
Multiple injuries were reported, but the exact nature of those injuries was not immediately disclosed.
The cause of the crash is under investigation, but police believe speed and rain contributed to the wreck.
The street closure is expected to last several hours, according to police.