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Frequently Asked Questions About TNS Recovery Complex

Source: Dermatology Associates

Q. How does this product work?
A. This product works by stimulating the skin's own natural healing processes. Wound healing proteins called "growth factors" stimulate the natural processes that result in new collagen formation, new elastic tissue, new healthy blood vessels and overall healing of sun damaged skin.

Q. How do I use this product?
A. Apply to skin twice daily.

Q. What type of results will I achieve and how long does it take?
A. Use of this product will make the skin texture appear smoother and make fine lines less visible. With continued use, it may help the skin achieve a more healthy appearance and much better elasticity and resilience.

Q. How long must I use this product?
A. A minimum of 3 months is recommended, but in general the longer it is used the better the results.

Q. What is the science behind this product?
A. Growth factors are naturally occurring proteins that control the wound healing process of the skin. These natural proteins result in new collagen formation, new elastic tissue, new blood vessel formation, as well as elimination of abnormal cells and structures in the skin. Our growth factors are natural byproducts of bio-engineered tissue collagen of human skin developed by Advanced Tissue Sciences. These growth factors have been studied extensively and are known to have a complete compliment of naturally occurring growth factors.

Q. What is NouriCel-MD?
A. NouriCel-MD is the professional strength of these naturally occurring growth factors, which is at least twice the strength of NouriCel. NouriCel-MD is available only through physician offices and physician directed sales.

Q. Are there any side effects?
A. No side effects have been detected in the use of these products. In fact, in more than 8,000 procedures using Advanced Tissue Sciences' burn and wound healing products (TransCyte and Dermagraft), there has not been a single adverse reaction nor rejection. These products contain the same growth factors as Nouri-Cel-MD.

Q. Can anyone use this product?
A: Yes. The presence of sun damage is a primary indication for the use of this product. Sun damage is an accumulative event and requires as little as six or seven minutes of sun exposure a day to result in sun damage that will progress and accumulate.

Q. What are the benefits of using this product? Specifically, what types of improvement will I be able to see in the skin?
A. The use of this product will result in making the skin texture appear smoother and make fine lines less visible. With continued use, it may help the skin achieve a more healthy appearance and much better elasticity and resilience.

Q. Will this product help with hyper-pigmentation?
A. It is thought that this product will result in more normal pigmentation, but studies have not been performed yet to prove or disprove this potential benefit.

Q. What is collagen?
A. Collagen is a protein fiber that is the basic building block of the skin and gives the skin structure and accounts for 70 percent of the dry weight of the skin. When sun damage occurs, the collagen is broken down and the skin loses it resilience and begins to sag and to crease more easily.

Q. What is the difference between growth hormones and growth factors?
A. Growth hormones are hormones that your body secretes to control growth of your entire body, as well as muscle growth and various other endocrine or internal factors. Growth factors are not hormones. They are wound healing regulatory proteins that control natural wound healing of the skin.

Q. Will growth factors improve scars?
A: Yes. Growth factors will improve scars most likely because they stimulate cells called "fibroblasts" to not only pick up abnormal collagen and dispose of it, but to lay down new collagen. This results in remodeling of scars, making them softer and smoother.

Q. Will this product improve fine lines, skin texture and wrinkles?
A. Use of this product will make the skin texture appear smoother and make fine lines less visible. With continued use, it may help the skin achieve a more healthy appearance and much better elasticity and resilience.

Q. What are epidermal growth factors?

A. Epidermal growth factor is the only growth factor that is been theoretically linked to potentially stimulating skin cancers to grow. There has been no clinical evidence of this happening, but nonetheless this particular growth factor is not present in this mixture because this mixture is made from thermal fibroblast cells.

Q. What is the active ingredient in TNS Recovery Complex?
A. TNS Recovery Complex contains NouriCel-MDä. NouriCel-MD is a professional strength concentration of Advanced Tissue Science's enriched nutrient solution by-product of growing tissue-engineered skin. This enriched nutrient solution contains human growth factors, soluble collagens, proteins, amino acids and powerful natural antioxidants.

Q. What growth factors are contained in NouriCel-MD and what do they do?
A. The NouriCel-MD ingredient contains Transforming Growth Factor-Beta (TGF-b), which is responsible for collagen secretion. Increased collagen fills in the depression under the wrinkles and restores the support structure of the skin. Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) are responsible for new blood vessel formation. New blood vessels deliver nutrients to the tissue. Keratinocyte Growth Factor (KGF) is responsible for epithelial cell growth. Interleukins are responsible for reduced inflammation. These growth factors work together like an orchestra and through their interaction have been scientifically proven to heal wounds.

Q. Are growth factors safe?
A. There have been more than 8000 procedures to date utilizing Advanced Tissue Sciences burn and wound healing products, TransCyteâ and Dermagraftâ with not one adverse reaction or rejection. NouriCel-MD does not contain Epidermal Growth Factor (EGF) because it is made from dermal fibroblast cells. EGF is the only growth factor that has been linked to cancerous cell growth and division. All safety testing on NouriCel-MD has resulted in no experimental irritation or adverse reaction.

Q. What are dermal fibroblasts?
A. The skin loses about 1 percent of its fibroblasts and thickness per year. Dermal fibroblasts are the "architects" or framework of the dermis. Fibroblasts produce new collagen fibers, which plump the skin from underneath. Collagen keeps skin strong and dense. The loss of collagen and elastin causes a breakdown of resiliency and skin thickness, which causes lines and wrinkles to result. Upon reaching adulthood, the dermis becomes thinner and the fibroblasts fewer, which translates into aging skin.

Q. Do I have to see a physician in order to acquire the TNS Recovery Complex?
A. Yes, the TNS Recovery Complex is part of an overall medically supervised skin care regimen.

Q. Are there other products on the market containing NouriCel-MD?
A. No, SkinMedica has the exclusive rights to NouriCel-MD in the medical market. NouriCel-MD is double the strength of NouriCelä and will only be available through physicians.

Q. Does the TNS Recovery Complex help to reverse sun damage?
A. Yes, studies have shown that sun damaged skin has 35 percent fewer capillaries than normal skin. New fine capillaries are required to repair the skin. The growth factors present in TNS Recovery Complex have the ability to form new blood vessels and capillaries. All tissue nutrients are delivered via capillaries.

Q. Does the TNS Recovery Complex contain irritating ingredients like alpha hydroxy acids?
A. No, the TNS Recovery Complex does not contain any retinols, AHA's or BHA's.

Q. Will the TNS Recovery Complex increase sensitivity to the sun?
A. No, the TNS Recovery Complex will not increase sensitivity to the sun.

Q. How many patients has the TNS Recovery Complex been tested on?
A. There is currently a 210 patient study underway across 7 leading dermatology / plastic surgery centers. Prior to that, over 30 patients have participated in 30 and 60-day studies.

Q. What are the active ingredients in NouriCel?
A. NouriCel is Advanced Tissue Science's enriched nutrient solution by-product of growing tissue-engineered skin. This enriched nutrient solution contains natural human growth factors, soluble collagens, proteins, amino acids and powerful antioxidants. These are the same chemicals that are readily present in newborn skin.

Q. What growth factors are contained in NouriCel and how do they work?
A. NouriCel contains Transforming Growth Factor-Beta (TGF-b), which is responsible for collagen secretion. Increased collagen fills in the depression under the wrinkles and restores the support structure of the skin. Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) are responsible for new blood vessel formation. New blood vessels deliver nutrients to the tissue. Keratinocyte Growth Factor (KGF) is responsible for epithelial cell growth. Interleukins are responsible for reduced inflammation. These growth factors work together like an orchestra and through their interaction have been scientifically proven to heal wounds.

Q. Are growth factors safe?
A. There have been more than 5,000 procedures to date utilizing Advanced Tissue Sciences burn and wound healing products, TransCyteâ and Dermagraftâ with not one adverse reaction or rejection. NouriCel does not contain Epidermal Growth Factor (EGF) because it is made exclusively from dermal fibroblast cells. EGF is the only growth factor that has been linked to cancerous cell growth and division. All safety testing on NouriCel has resulted in no experimental irritation or adverse reaction.

Q. What are dermal fibroblasts?
A. Dermal fibroblasts are the "architects" or framework of the dermis. The skin loses about 1 percent of its fibroblasts and thickness per year. Fibroblasts produce new collagen fibers, which plump the skin from underneath. Collagen keeps skin strong and dense. The loss of collagen and elastin causes a breakdown of resiliency and skin thickness, which causes lines and wrinkles to result. Upon reaching adulthood, the dermis becomes thinner and the fibroblasts fewer, which translates into aging skin.

Q. Where do the dermal fibroblast cells come from?
A. Neonatal foreskins have been donated by parents to help burn and wound victims. Normally, this tissue would be disposed of in the surgical process. The epidermal layer of skin is separated from the dermal layer and the cells from the dermal layer, dermal fibroblasts, are used for growing human tissue. This tissue helps burn victims to heal faster, with less scarring and reduced pain. It also heals chronic diabetic foot ulcers helping patients avoid infection and possible amputation.

Q. What testing procedures are used to test the dermal fibroblast cells?
A. Advanced Tissue Sciences' master cell bank has been safety tested and approved by the United States Food and Drug Administration. Cells undergo testing for all know antigens and pathogens including HIV.

Q. Does NouriCel help to reverse sun damage?
A. Yes, studies have shown that sun damaged skin has 35 percent fewer capillaries than normal skin. New fine capillaries are required to repair the skin. The growth factors present in NouriCel have the ability to form new blood vessels and capillaries. All nutrients are delivered to the tissue via capillaries.

Q. Does NouriCel contain irritating ingredients like alpha hydroxy acids or Retinol?
A. No, NouriCel does not contain any Retinol, AHA's or BHA's.

Q. Will NouriCel increase my sensitivity to the sun?
A. No, NouriCel will not increase sensitivity to the sun.

Q. How many patients has NouriCel been tested on?
A. There is currently a 270 patient study underway across 9 leading dermatology/ plastic surgery centers, a 36 patient study at Dermtech (formerly known as the California Skin Research Institute) and another 30 patient study at Dermtech. Prior to that, over 30 patients have participated in 30 and 60-day studies.

Q. How is the performance of NouriCel optimized?
A. Early clinical testing has shown improved results when used in combination with regular exfoliation. Exfoliation eliminates dead cells, opens the pores and allows NouriCel to penetrate the skin.

Q. How do we get wrinkles?
A. The skin has three layers - the epidermis, dermis and sub-dermis. The second layer, the dermis, contains the blood vessels that nourish the skin. It also contains the structural elements, or proteins, called collagen and elastin. These proteins are what keep the skin taut and springy. Skin hardens from use, loses its support and molds into "voids" -- causing wrinkles. As we age (everyday wear and tear), and as our skin is exposed to environmental stresses, such as pollution and the sun, the collagen and elastin proteins in our skin begin to break down (creating voids), and are produced by the body at a much slower rate than when we were younger. These "gaps" are wrinkles.

Q. What is Collagen and why do we need more of it?
A. Collagen is a natural protein, produced by your body, which resides in the dermis and sub-dermis, or lower two layers of the skin. Collagen is a necessary protein to help your skin maintain its durability and resilience. Without it, your skin will not remain taut, and wrinkles will form.

Q. Is NouriCel patented?
A. Advanced Tissue Sciences has over 40 patents and hundreds of millions of capital invested in its innovative core technology of three-dimensional tissue engineering. This is the same process that is used to make NouriCel.

Q. What is Elastin?
A. Elastin is a natural protein, produced by your body, which resides in the dermis and sub-dermis, or lower two layers of the skin. Elastin is a necessary protein to help your skin maintain its flexibility. Without it, your skin will not remain taut and springy, and wrinkles will form.

Q. Explain the layers of the skin?
A. Skin is the outside covering of body tissue, which protects inner cells and organs from the outside environment. We have 3 distinct layers of skin. The outer layer is the epidermis. The second layer, the dermis, is thick, sturdy, rich in blood vessels, shields and repairs injured tissue, and is the layer in which your collagen and elastin supplies originate. The lowest layer, or sub-dermis, acts as our insulator and source of energy. This is where the profound skin regeneration occurs.

Q. What makes NouriCel unique?
A. NouriCel is the only product on the market that contains the same natural chemicals that newborn baby skin has including a unique combination of human growth factors, powerful antioxidants, proteins, hyaluronic acid and soluble collagens. Advanced Tissue Sciences is uniquely qualified to supply NouriCel to the market as a result of our extensive capital investment in the tissue engineering process and strong patent position.

Q. Can younger people use NouriCel-containing products?
A. Many factors influence the skin's tendency to wrinkle only one of which is age. Our environment, sun, stress, diet, even our emotions all affect how our skin holds up, as we get older. Products containing NouriCel-MD or NouriCel are for people of any age who would like to prevent or eliminate wrinkles.


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