SAN DIEGO -- A 23-year-old woman on her way home after a late-night shift at a Burger King was killed Friday when a softball-sized rock crashed through a car window and struck her in the head in Linda Vista, police said.

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WOMAN KILLED Images: Crime Scene Video: Rock Through Window Kills Woman

Someone in a vehicle traveling in the opposite direction just after 2 a.m. apparently threw the rock that struck Yadira Guzman, who was riding in a car with her husband in the 3200 block of Genesee Avenue, according to San Diego police homicide Lt. Kevin Rooney.

Guzman's husband, Javier Manzanares, sped a short distance back to their home in the 6600 block of Kelley Street and called authorities at about 2:10 a.m., Rooney said.

Guzman was pronounced dead at 2:24 a.m., Medical Examiner's officials said.

Other motorists driving in the communities of Linda Vista, La Jolla, Clairemont and Miramar reported someone in a vehicle throwing rocks at cars over a 70-minute span beginning just before 1 a.m., Rooney said.

They were at:

Interstate 805 at Miramar
La Jolla Parkway at Torrey Pines
Hidden Valley at Torrey Pines
Clairemont Mesa at Genessee

Police say since Monday, there have been 16 reports of rocks being thrown at vehicles while the motorists were driving. The vehicles were damaged, but no other motorists were injured.

"I want the person or persons responsible for this to know that we have a team of homicide investigators working around the clock to bring them to justice," Assistant Chief Rulette Armstead said.

San Diego police officials are working with the California Highway Patrol to determine whether similar incidents have been reported on local highways, CHP Capt. John Bailey said.

The suspect vehicle has been described by various witnesses as a pickup truck, a SUV and a sedan, Rooney said.

"I am open to the possibility that we are looking for more than one person or more than one vehicle. We just don't know for sure," Rooney said. "We need the public's help on this one."

Anyone with information about the incident was asked to call San Diego police at (619) 531-2293 or the Crime Stoppers anonymous tip line at (888) 580-TIPS.